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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 4
1994 14
1995 15
1996 33
1997 39
1998 66
1999 71
2000 65
2001 74
2002 73
2003 65
2004 66
2005 71
2006 82
2007 71
2008 78
2009 73
2010 90
2011 75
2012 74
2013 56
2014 72
2015 85
2016 103
2017 83
2018 77
2019 82
2020 84
2021 89
2022 59
2023 58
2024 14

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1,924 results

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Page 1
Biomarker-Guided Development of DNA Repair Inhibitors.
Cleary JM, Aguirre AJ, Shapiro GI, D'Andrea AD. Cleary JM, et al. Mol Cell. 2020 Jun 18;78(6):1070-1085. doi: 10.1016/j.molcel.2020.04.035. Epub 2020 May 26. Mol Cell. 2020. PMID: 32459988 Free PMC article. Review.
For example, defects in homologous recombination (HR) repair arise in cancer cells through inherited or acquired mutations in BRCA1, BRCA2, or other genes in the Fanconi anemia/BRCA pathway, and these tumors have been shown to be particularly sensitive to inhibitors …
For example, defects in homologous recombination (HR) repair arise in cancer cells through inherited or acquired mutations in BRCA1, …
BRCA1 as target for breast cancer prevention and therapy.
Romagnolo AP, Romagnolo DF, Selmin OI. Romagnolo AP, et al. Anticancer Agents Med Chem. 2015;15(1):4-14. doi: 10.2174/1871520614666141020153543. Anticancer Agents Med Chem. 2015. PMID: 25329591 Review.
Although BRCA1 acts as a tumor suppressor and is present in all cells, where it is essential for the maintenance of the genome integrity, it is still not clear why mutations in the BRCA1 gene predispose to breast and ovarian, but not to other types of cancer. ...The …
Although BRCA1 acts as a tumor suppressor and is present in all cells, where it is essential for the maintenance of the genome integr …
Role of BRCA1 and BRCA2 as regulators of DNA repair, transcription, and cell cycle in response to DNA damage.
Yoshida K, Miki Y. Yoshida K, et al. Cancer Sci. 2004 Nov;95(11):866-71. doi: 10.1111/j.1349-7006.2004.tb02195.x. Cancer Sci. 2004. PMID: 15546503 Free article. Review.
BRCA1 (BReast-CAncer susceptibility gene 1) and BRCA2 are tumor suppressor genes, the mutant phenotypes of which predispose to breast and ovarian cancers. Intensive research has shown that BRCA proteins are involved in a multitude of pivotal cellular processes. In p …
BRCA1 (BReast-CAncer susceptibility gene 1) and BRCA2 are tumor suppressor genes, the mutant phenotypes of which predispose to …
Breast cancer genes: beyond BRCA1 and BRCA2.
Filippini SE, Vega A. Filippini SE, et al. Front Biosci (Landmark Ed). 2013 Jun 1;18(4):1358-72. doi: 10.2741/4185. Front Biosci (Landmark Ed). 2013. PMID: 23747889 Free article. Review.
Familial breast cancer (about 30 percent of patients), often seen in families with a high incidence of BC, has been associated with a number of high-, moderate-, and low-penetrance susceptibility genes. Family linkage studies have identified high-penetrance genes, …
Familial breast cancer (about 30 percent of patients), often seen in families with a high incidence of BC, has been associated with a number …
BRCA Genes and Related Cancers: A Meta-Analysis from Epidemiological Cohort Studies.
Lee YC, Lee YL, Li CY. Lee YC, et al. Medicina (Kaunas). 2021 Aug 30;57(9):905. doi: 10.3390/medicina57090905. Medicina (Kaunas). 2021. PMID: 34577828 Free PMC article. Review.
Background and Objectives:BRCA1 and BRCA2 are genes located in different chromosomes that are disproportionately associated with hereditary breast and ovarian cancer syndrome. ...Conclusion: The meta-analysis results can provide clinicians and relevant families with …
Background and Objectives:BRCA1 and BRCA2 are genes located in different chromosomes that are disproportionately associated wi …
Comprehensive spectrum of BRCA1 and BRCA2 deleterious mutations in breast cancer in Asian countries.
Kwong A, Shin VY, Ho JC, Kang E, Nakamura S, Teo SH, Lee AS, Sng JH, Ginsburg OM, Kurian AW, Weitzel JN, Siu MT, Law FB, Chan TL, Narod SA, Ford JM, Ma ES, Kim SW. Kwong A, et al. J Med Genet. 2016 Jan;53(1):15-23. doi: 10.1136/jmedgenet-2015-103132. Epub 2015 Jul 17. J Med Genet. 2016. PMID: 26187060 Free PMC article. Review.
Approximately 5%-10% of breast cancers are due to genetic predisposition caused by germline mutations; the most commonly tested genes are BRCA1 and BRCA2 mutations. Some mutations are unique to one family and others are recurrent; the spectrum of BRCA1/BRCA2 …
Approximately 5%-10% of breast cancers are due to genetic predisposition caused by germline mutations; the most commonly tested genes …
The BRCA1 and BRCA2 Genes in Early-Onset Breast Cancer Patients.
Saleem M, Ghazali MB, Wahab MAMA, Yusoff NM, Mahsin H, Seng CE, Khalid IA, Rahman MNG, Yahaya BH. Saleem M, et al. Adv Exp Med Biol. 2020;1292:1-12. doi: 10.1007/5584_2018_147. Adv Exp Med Biol. 2020. PMID: 29687286 Review.
Approximately 5-10% of breast cancers are attributable to genetic susceptibility. Mutations in the BRCA1 and BRCA2 genes are the best known genetic factors to date. The goal of this study was to determine the structure and distribution of haplotypes of the BRCA1 …
Approximately 5-10% of breast cancers are attributable to genetic susceptibility. Mutations in the BRCA1 and BRCA2 genes are t …
The breast cancer susceptibility genes (BRCA) in breast and ovarian cancers.
Paul A, Paul S. Paul A, et al. Front Biosci (Landmark Ed). 2014 Jan 1;19(4):605-18. doi: 10.2741/4230. Front Biosci (Landmark Ed). 2014. PMID: 24389207 Free PMC article. Review.
The Breast Cancer Susceptibility Genes, BRCA1 and BRCA2, are the dynamic regulators of genomic integrity. ...Mutations of BRCA1/2 genes greatly increase lifetime risk to develop breast and ovarian cancer and these mutations are frequently observed in h …
The Breast Cancer Susceptibility Genes, BRCA1 and BRCA2, are the dynamic regulators of genomic integrity. ...Mutations of B …
BRCA1: An Endocrine and Metabolic Regulator.
Werner H. Werner H. Front Endocrinol (Lausanne). 2022 Mar 31;13:844575. doi: 10.3389/fendo.2022.844575. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 35432218 Free PMC article. Review.
While the genomic and cancer-related actions of BRCA1 have been extensively investigated, not much information exists regarding the cellular and circulating factors involved in regulation of BRCA1 expression and action. ...Experimental and clinical evidence links …
While the genomic and cancer-related actions of BRCA1 have been extensively investigated, not much information exists regarding the c …
1,924 results